Select Publications

Comprehensive list at Google Scholar and ORCIDORCID iD icon
Members of the Lange Lab in underlined.


Preprints – Feedback welcome!


Peer-reviewed publications

Proteogenomic analysis identifies the persistence of targetable lesions and proteomes through disease evolution in pediatric acute lymphoblastic leukemia

Lorentzian, Amanda C and Guo, Meiyun and Ergin, Enes K and Akella, Neha M and Rolf, Nina and Lim, C James and Reid, Gregor SD and Maxwell, Christopher A and Lange, Philipp F
medRxiv 2022
open access – now accepted in Nature Communications

Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation

He Z, Ghorayeb R, Tan S, Chen K, Lorentzian A, Bottyan J, Aalam SMM, CIMBA Consortium; Pujana MA, Lange PF, Kannan N, Eaves CJ, Maxwell CA
Nature Communications 2022
open access

Sensitive identification of known and unknown protease activities by unsupervised linear motif deconvolution

Anuli C. UzozieTheodore G. Smith, Siyuan Chen Philipp F. Lange
Analytical Chemistry 2022
open access

Modification of BRCA1-associated breast cancer risk by HMMR overexpression

Mateo F, He Z, Me L, Garibay GR, Herranz C, Garcia N, Lorentzian A, Baiges A, Blommaert E, Gomez A, Mirallas O, Garrido-Utrilla A, Palomero L, Espin R, Extremera AI, Soler T, Petit A, Cimba, Li R, Brunet J, Chen K, Tan SXS, Eaves CJ, McCloskey C, Hakem R, Khokha R, Lange PF, Lazaro C, Maxwell CA#, Pujana PA#
Nature Communications 2021
open access

Multi-omic profiling of the leukemic microenvironment shows bone marrow interstitial fluid is distinct from peripheral blood plasma

Lorenz Nierves, Jian Guo, Siyuan Chen, Janice Tsui, Anuli Uzozie, Jonathan W. Bush, Tao Huan, Philipp F. Lange
Exp Hematol Oncol 2022
open access

Robust unsupervised deconvolution of linear motifs characterizes 68 protein modifications at proteome scale

Theodore G. Smith, Anuli C. Uzozie, Siyuan Chen, Philipp F. Lange
Scientific Reports 2021
open access

PDX models reflect the proteome landscape of pediatric acute lymphoblastic leukemia but divert in select pathways

Uzozie A, Ergin EK, Rolf N, Tsui J, Lorentzian A, Weng SH, Nierves L, Smith TG, Lim CJ, Maxwell C, Reid GS, Lange PF
Journal of Experimental and Clinical Cancer Research 2021
open access

Detectability of biotin tags by LC-MS/MS

Nierves LLange PF
Journal of Proteome Research 2021
Journal page

Sensitive determination of proteolytic proteoforms in limited microscale proteome samples

Samuel SH Weng, Fatih Demir, Enes K. Ergin, Sabrina Dirnberger, Anuli Uzozie, Domenic Tuscher, Lorenz Nierves, Janice Tsui, Pitter F. Huesgen and Philipp F. Lange
Molecular & Cellular Proteomics 2020
open access

Origins and clinical relevance of proteoforms in pediatric malignancies

A Lorentzian, A Uzozie, Philipp F Lange
Expert review of proteomics 2019
open access

Tumor variant identification that accounts for the unique molecular landscape of pediatric malignancies

A Lorentzian, JA Biegel, DG Ostrow, SR Rassekh, RJ Deyell, T Triche, K Schultz, J Rozmus, GSD Reid, CJ Lim, PF Lange#, CA Maxwell#
J National Cancer Institute (JNCI) – Cancer Spectrum 2019
open access

  • Yu H, Xing S, Nierves L, Lange PF, Huan T. Implementing quality control-based signal calibration in mass spectrometry-based metabolomics to overcome the error of fold change calculation caused by nonlinear ESI responsesAnalytical Chemistry (2020)
  • Richmond AP, Kloet F, Vaz FM, Kampen AHC, Uzozie A, Lange PF, Lin D, Kobor M, Graham E, Mostafavi S, Moreland P, Wasswerman W, Karnebeek C, Kemp S, Engelen M, Multi-omic approach to identify phenotypic modifiers underlying cerebral demyelination in X-linked adrenoleukodystrophy Frontiers in Cell and Developmental Biology
  • Connell M, Chen H, Jiang J, Kuan C-W, Fotovati A, Chu T, He Z, Lengyell TC, Li H, Kroll T, Li AM, Goldowitz D, Frappart L, Ploubidou A, Patel M, Pilarski LM, Simpson EM, Lange PF, Allan DW, Maxwell CA. HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development. eLIFE. 2017 Oct 10;6. pii: e28672.
  • Prudova A, Gocheva V, Auf dem Keller U, Eckhard U, Olson OC, Akkari L, Butler GS, Fortelny N, Lange PF, Mark JC, Joyce JA, Overall CM. TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors. Cell Reports. 2016 Aug 9;16(6):1762-73.
  • Fotelny N, Yang S, Pavlidis P, Lange PF#, Overall CM#. Proteome TopFIND3.0 with TopFINDer and PathFINDer: database analysis tools for the association of protein termini to pre- and post-translational events. Nucleic Acids Research. 2015 Jan;43(Database issue):D290-7. (# joint corresponding author)
  • Pitter F Huesgen, Philipp F Lange , Lindsay D Rogers, Nestor Solis, Ulrich Eckhard, Oded Kleifeld, Theodoros Goulas, F Xavier Gomis-Rüth & Christopher M Overall (2014). LysargiNase mirrors trypsin for protein C-terminal and methylation-site identification Nature Methods 12, 55–58 (2015)
  • Nikolaus Fortelny, Jennifer Cox, Reinhild Kappfelhoff, Amanda E. Starr, Philipp F. Lange, Paul Pavlidis, Christopher M. Overall (2014). Network Analyses Reveal Pervasive Functional Regulation Between Proteases in the Human Protease Web PLoS Biology, 12(5):e1001869. PMID: 24865846.
  • Philipp F Lange*, Pitter F Huesgen*, Karen Nguyen, Christopher M Overall (2014) Annotating N termini for the Human Proteome Project: N termini differentiate stable processed protein species from degradation remnants in the human erythrocyte proteome. Journal of Proteome Research13 (4), 2028-2044 (* joint first authors)
  • Huesgen PF*, Lange PF*, Overall CM (2014) Ensembles of protein termini are sensitive and specific proteolytic signature biomarkers of disease, Proteomics – Clinical Applications (* joint first authors)
  • Lange PF, Overall CM (2013) Protein TAILS: When termini tell tales of proteolysis and function. Current Opinion in Chemical Biology 17(1):73-82
  • Philipp F. Lange, Pitter F. Huesgen, Christopher M. Overall (2012). TopFIND 2.0—linking protein termini with proteolytic processing and modifications altering protein functionNucleic Acids Research. 40(D1): D351-D361.
  • Philipp F. Lange & Christopher M. Overall (2011). TopFIND, a knowledgebase linking protein termini with functionNature Methods 8: 703–704.
  • auf dem Keller U, Bellac CL, Li Y, Lou Y, Lange PF, Ting R, Harwig C, Kappelhoff R, Dedhar S, Adam MJ, Ruth TJ, Bénard F, Perrin DM, Overall CM (2010). Novel matrix metalloproteinase inhibitor [18F]marimastat-­‐aryltrifluoroborate as a probe for in vivo positron emission tomography imaging in cancerCancer Research 1;70(19):7562-­9.
  • Philipp F. Lange, Lena Wartosch, Thomas J. Jentsch, Jens C. Fuhrmann (2006). ClC–7 requires Ostm1 as a β–subunit to support bone resorption and lysosomal functionNature 440: 220–223.